Project Overview

The AMR IRG is an interdisciplinary community of biologists, engineers, and clinicians from MIT and Singapore, sharing a state-of-the art research facility and united by a commitment to providing a supportive intellectual environment where students and staff can learn, grow, and contribute to solving a pressing societal problem.

The objective of this project is to develop and apply an integrated drug discovery platform for RNA-modifying enzymes, with a focus on identifying and advancing small-molecule inhibitors with therapeutic potential. By combining cell-based compound screening, quantitative LC-MS/MS analysis of RNA modifications, target engagement assessment, and disease-relevant validation, this project will enable systematic discovery of drug candidates, pharmacodynamic biomarkers, and actionable RNA modification pathways for future therapeutic development.

Responsibilities

The Research Engineer will plan and conduct experiments to support the validation and advancement of RNA modification–targeted drug discovery projects. The candidate will work on cell culture, compound treatment, RNA isolation, LC-MS/MS-based RNA modification analysis, and functional assays to assess drug mechanism of action and efficacy in relevant cell models. Responsibilities will also include assay optimization, data organization and interpretation, preparation of results for reports and publications, coordination with the AMR IRG community and external collaborators, and development of strong experimental, analytical, and communication skills.

Requirements

B.S. or M.S. in biochemistry, molecular and cell biology, bioengineering, chemical engineering, pharmaceutical sciences, or a related field. Prior experience in mammalian cell culture, RNA extraction, HPLC, LC-MS/MS, molecular biology techniques, or cell-based assays is preferred. Experience in drug discovery, pharmacology, or assay development would be an advantage but is not required. Strong oral and written communication skills in English, good organizational skills, and the ability to work both independently and collaboratively as part of a team.

To apply, please visit our website at: https://portal.smart.mit.edu/careers/career-opportunities

Interested applicants are invited to send in their full CV/resume, cover letter and list of three references (to include reference names and contact information). We regret that only shortlisted candidates will be notified.